536 research outputs found
Straight Line Orbits in Hamiltonian Flows
We investigate periodic straight-line orbits (SLO) in Hamiltonian force
fields using both direct and inverse methods. A general theorem is proven for
natural Hamiltonians quadratic in the momenta in arbitrary dimension and
specialized to two and three dimension. Next we specialize to homogeneous
potentials and their superpositions, including the familiar H\'enon-Heiles
problem. It is shown that SLO's can exist for arbitrary finite superpositions
of -forms. The results are applied to a family of generalized H\'enon-Heiles
potentials having discrete rotational symmetry. SLO's are also found for
superpositions of these potentials.Comment: laTeX with 6 figure
A Novel TRAF3IP2 Mutation Causing Chronic Mucocutaneous Candidiasis
Inborn errors of the IL-17-mediated signaling have been associated with chronic mucocutaneous candidiasis (CMC). We describe a patient with CMC, atopic dermatitis, enamel dysplasia, and recurrent parotitis harboring a novel compound heterozygous mutation of TRAF3IP2, leading to autosomal recessive ACT1 deficiency and deficient IL-17 signaling.info:eu-repo/semantics/publishedVersio
A global Carleman estimate in a transmission wave equation and application to a one-measurement inverse problem
We consider a transmission wave equation in two embedded domains in ,
where the speed is in the inner domain and in the outer
domain. We prove a global Carleman inequality for this problem under the
hypothesis that the inner domain is strictly convex and . As a
consequence of this inequality, uniqueness and Lip- schitz stability are
obtained for the inverse problem of retrieving a stationary potential for the
wave equation with Dirichlet data and discontinuous principal coefficient from
a single time-dependent Neumann boundary measurement
Homeomorphic Embedding for Online Termination of Symbolic Methods
Well-quasi orders in general, and homeomorphic embedding in particular, have gained popularity to ensure the termination of techniques for program analysis, specialisation, transformation, and verification. In this paper we survey and discuss this use of homeomorphic embedding and clarify the advantages of such an approach over one using well-founded orders. We also discuss various extensions of the homeomorphic embedding relation. We conclude with a study of homeomorphic embedding in the context of metaprogramming, presenting some new (positive and negative) results and open problems
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis
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